Multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) threaten global progress towards the targets of the End TB Strategy set by the World Health Organization (WHO). Table 4. Both linezolid and cycloserine are known for their high frequency of serious adverse events. 2019 Dec 25;9(1):55. doi: 10.3390/jcm9010055. Clipboard, Search History, and several other advanced features are temporarily unavailable. Injectable agents are no longer among the priority medicines. HHS  |  treatment guidelines for drug-resistant TB, 2016 update, 9–11 November 2015 . USAID Contract No. ®mĊT-P¶°ÃÌÌ3Îèfµ96´¹0sš–֐ŽØª@º¥½ª2•'Ëy ÔŠ²aX+ÎÚ!º•ZšÕɪÊëo53›jL€5šð¯CJÅæ\é[‘Sr¼[7”Åœ"ÆU"U›Ü¢šq‘Ž(9õbÏUY0rDãiX˚56Mo¶HÕÅY°™˜VØaíF³ÜÓµ)5%½ð]: ‰çÌÌR&,V3˅ð÷Ù{Ûmt©zÝ6[kïú+¸5%üzvÇ»Ä[ÏbD5ØH`ak/BvÀ&ðÀ†£Û¦ØÁ¡ 5‡RìIèXepQ(¨ˆ eb€Ÿ‚m>6£ß÷–àc(YŖ!$Ç9G±W0c3¸X²šÅ±§#lS‚á’e[>''$\V?ÊU9ËBì|bð)n`‘w^$Éäú'±l>'ênçØçqÓêXfGA!ލàž0÷ÿõq %MHðÜAð&ào. 16 In 2018, WHO convened a Guideline Development Group (GDG) to update its policy recommendations on the treatment of MDR/RR-TB. Rapid Communication: Key changes to treatment of multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) Authors: WHO. Sitemap, Infection Prevention and Control in Hospitals: FAST, National TB Guidelines, Policies and Plans, Management of Rifampicin resistant Tuberculosis: A Clinical Reference Guide, The Shorter Regimen for RR-TB: Summary Points, Principles of the Shorter Treatment Regimen in Children Aged 6 Years and Above, Switching from Shorter Regimen to Longer Regimen, Longer Regimens for RR-TB: Summary Points, Principles of Longer Treatment Regimens in Children Under the Age of 6 Years, Approach to Designing Rescue Regimens or Regimens for Patients with RR-TB and Suspected or Confirmed Resistance to Linezolid, Clofazimine and/or Bedaquiline, Summary Principles on HIV and RR-TB Co-Infection, Antiretroviral Therapy in HIV-Infected Persons with RR-TB, Management of Antiretroviral Therapy in Persons with RR-TB, Summary Principles for Monitoring and Management of Adverse Events, Management of Patients with QT Interval Prolongation, Management of Patients with Peripheral Neuropathy, Management of Patients with Hepatotoxicity, Summary Activities for Active Drug Safety Monitoring, Contact Evaluation and Post-Exposure Management: Summary, Rifampicin Resistant TB Patients Household Contacts, Drug-Resistant TB that is not Rifampicin-Resistant: summary, Management of Drug-Resistant TB that is not Rifampicin-Resistant, Summary Points on Palliative and End-of-Life Care, Summary Points on Post-Treatment Follow Up. 21 December 2018 - Multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) threaten global progress towards the targets of the End TB Strategy set by the World Health Organization (WHO). The final STREAM results have confirmed the non-inferiority of the short regimen compared with the long regimen. The emergence of drug-resistant TB is a major global health concern, which threatens the ambitious goals and progress set under the End TB Strategy. . Additional trial data from patients under 18 years of age allowed a review of recommendations for use of bedaquiline and delamanid in children. The 9-11 month regimen consists of a “package” of seven medications (bedaquiline, linezolid, clofazimine, levofloxacin, high-dose isoniazid, pyrazinamide and ethambutol), with an intensive phase lasting 4-6 months and a continuation phase lasting 5 months. Have confirmed the non-inferiority of the complete set of features a standardized month...: management of fluoroquinolone-resistant MDR-TB following the WHO guidelines, Search History, and clinical:! With conventional regimens or with limited treatment options great promise or disappointment polyresistant ) second-line! 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